A world-first! The 146 Longevity Medical Management Model has been officially launched, empowering the development of the longevity economy.

Recently, a research team led by Tian Dongwei at the Guangdong Sheba Life Science Research Institute has officially launched the "146 Longevity Medicine Management Model" to the global community, fully disclosing its comprehensive system architecture comprising "1 core technology, 4 major intervention modules, and a 6-step precision management closed-loop." This innovative model precisely addresses key industry pain points in China's longevity health management sector—such as the lack of standardization, challenges in large-scale implementation, high dependence on expert resources, and insufficient personalized interventions—by providing complete theoretical support and a practical implementation framework for the standardized development, chain-based replication, and market-oriented deployment of longevity medicine, thereby contributing to the high-quality transformation and development of China's broader healthcare industry, public wellness sectors, and the longevity economy.

Addressing industry pain points directly! The innovative 146 System establishes a new benchmark for longevity medicine.

Currently, China's longevity health management industry has long faced three major development bottlenecks: the absence of unified standards for services, a heavy reliance on seasoned experts in operations, and the difficulty of balancing standardized, large-scale operations with personalized, precise interventions; these factors have led to severe homogenization within the industry, inconsistent service quality, weak sustainable operational capabilities, and frequent instances of industry misconduct where "longevity institutions fail to achieve longevity."

To address the shortcomings in the industry, Dr. Tian Dongwei's team at the Guangdong Sheba Life Science Research Institute has dedicated itself to the field of aging intervention by integrating cutting-edge global scientific research and clinical achievements, thereby innovatively establishing a "Standardized Rigid Framework + Individualized Flexible Intervention" model for longevity medicine. This comprehensive system is built upon proprietary core technologies as its foundation, supported by tiered intervention modules, and backed by a full-chain closed-loop management mechanism; it effectively overcomes the fragmented drawbacks of traditional health management approaches, enabling the model to be packaged for distribution, replicated across China through chain operations, and implemented with standardized operational processes.

I. One core technology: Independent and controllable FMT microbiota transplantation, which strengthens technical barriers.

The "146 Longevity Medicine Management Model" employs standardized fecal microbiota transplantation (FMT) as its sole core foundational technology, thereby building a differentiated institutional advantage and high-barrier core competitiveness. Distinct from the development models adopted by most institutions on the market—those that merely follow popular short-term trends without establishing proprietary core technologies—the team leverages its locally adapted FMT technology, developed through long-term clinical refinement and iterative optimization. This approach enables the establishment of a comprehensive microecological regulation system; all health interventions and anti-aging wellness services are centered around maintaining intestinal microecological homeostasis, thereby creating a long-term technological moat and addressing the issue of technical hollowing within the industry at its root.

II. Four major stratified intervention modules: covering the health needs of all populations throughout their entire life cycle

This new model innovatively establishes a four-dimensional stratified intervention system—covering the prevention of major diseases, management of chronic diseases, anti-aging measures, and extension of lifespan—based on the human aging process and disease risk levels. It precisely addresses the essential healthcare needs of people across all age groups and with varying health statuses, thereby overcoming the limitations of traditional health services that often remain singular in approach.

1. Prevention of major diseases: Mitigates the risk of severe critical illnesses;

This initiative focuses on major diseases with high mortality and disability rates—such as malignant tumors, acute myocardial infarction (AMI), and ischemic stroke—by abandoning the traditional delayed screening model of routine health check-ups. Leveraging cutting-edge technologies—including multi-omics testing, dynamic biological age tracking, three-dimensional vascular imaging, and millimeter-level high-precision imaging screening—it enables early risk warning during the asymptomatic phase of these diseases. By integrating 24-hour wearable device-based dynamic monitoring, assessment of vascular plaque stability, and personalized blood pressure and lipid threshold management, the system can automatically detect precursors to AMI or cerebral infarction, increase the frequency of follow-up interventions for high-risk individuals, achieve 99% early prevention and control of high-risk severe diseases, and thereby mitigate the risk of sudden onset of advanced-stage severe conditions at their source.

2. Managing chronic diseases: overcoming the challenge of lifelong medication adherence

This program precisely targets the high-risk middle-aged and young adult population aged 35–65, focusing on three prevalent chronic diseases: hypertension, type 2 diabetes mellitus, and endocrine dysfunction. Building upon established intervention protocols that have been introduced and validated through over a decade of local clinical trials, the program provides comprehensive clinical monitoring to accurately trace the root causes of these chronic conditions. Coupled with a personalized lifestyle intervention system, it assists patients in safely reducing or discontinuing their medication, while enabling long-term stabilization of blood pressure, blood glucose levels, and endocrine parameters within normal clinical ranges—thereby effectively addressing the industry challenge of lifelong medication adherence for chronic diseases.

3. Anti-aging: Quantitatively reversing the biological aging process

Modern medicine has confirmed that aging is a chronic degenerative process that can be precisely intervened upon. The human body follows a well-defined aging pattern: women reach peak physiological function at age 28; at age 35, reproductive function declines rapidly; at age 42, visible signs of aging emerge in hair and bone structure; at age 49, following menopause, the aging process accelerates; while men exhibit a corresponding gradient of decline. This pattern can be addressed through three-dimensional synergistic regulation involving gut microbiota, endocrine system, and immune system, combined with long-acting, precision health management, enabling the precise quantification of organ aging rates, achieving a reversal of biological age, and scientifically reversing the aging state of the organism.

4. Extending lifespan: improving life expectancy

By abandoning the unscientific misconceptions surrounding "immortality" and centering our approach on evidence-based medicine, we can comprehensively eliminate modifiable aging risks and disease hazards in the human body, continuously narrow the gap between biological age and chronological age, reduce all-cause mortality rates, steadily extend the healthy lifespan of the population without pursuing extreme longevity, shorten the duration of survival while carrying underlying diseases, and ultimately achieve the core objective of "living long and healthy."

III. The 6-Step Precision Management Closed-loop (6P System): Enabling Scientific Whole-Chain Health and Wellness Care

To address the issues of fragmented traditional health management processes, interventions lacking evidence-based support, and maintenance efforts lacking long-term efficacy, the 146 Model establishes a six-step progressive closed-loop management system encompassing precise detection, precise prevention, precise treatment, precise clearance, precise regulation, and precise wellness care; this system ensures full-process standardization, traceability, and practical implementability.

1. Precision Detection: A three-layer, multi-dimensional approach to building a comprehensive health profile

Through a three-tiered diagnostic approach—comprising whole-genome susceptibility locus screening, functional medicine sub-health assessment, and conventional clinical organ examinations—this method systematically identifies: (1) congenital genetic risks; (2) potential aging and chronic disease risks over the next 2–3 years; and (3) the current actual health status of individual organs. This process establishes a comprehensive, multi-dimensional personal health database that provides precise evidence for subsequent interventions.

2. Precision Prevention: Comprehensive, end-to-end preemptive blockade of severe diseases

Establish comprehensive prevention and control systems for two major diseases—cardiovascular and cerebrovascular diseases, as well as tumors—by implementing dynamic monitoring of vascular vulnerable plaques, developing customized individualized indicator management standards, and utilizing wearable devices to capture real-time emergency warning signals; through high-precision imaging screening to detect early-stage microlesions, and by targeting the modification of carcinogenic triggers such as diet and environment, this approach enables proactive prevention before the onset of severe diseases and achieves comprehensive disease blockade.

3. Precision Medicine: Tracing the root cause to address the core issue and implementing scientific management of chronic diseases

We break away from the traditional misconception of relying solely on single medications to suppress disease indicators; instead, we utilize precision diagnostics to identify the underlying causative factors of chronic diseases and develop customized, full-lifecycle personalized intervention plans. Under the continuous supervision of a board-certified physician, these plans enable a gradual reduction or discontinuation of medication, thereby maintaining long-term stability of the body's metabolic and endocrine functions and addressing the root causes of chronic conditions.

4. Targeted Remediation: Comprehensive elimination of aging-related disease risks across all areas

Addressing the prevalent issues of overnutrition, accumulation of metabolic waste, and high incidence of chronic low-grade inflammation among contemporary populations, this approach regularly performs intestinal toxin metabolism clearance and regulates vascular lipid plaques, systematically eliminates systemic inflammatory factors, blocks the core pathways through which inflammation drives aging and the progression of chronic diseases, and thereby strengthens the foundation of overall health.

5. Precise Regulation: Restoring the three major homeostatic mechanisms of the body

Centered around the three pillars of health—intestinal microbiota, endocrine hormones, and the immune system—we reject generalized or formulaic healthcare approaches. By precisely targeting the body's imbalances through the supplementation of microbiota nutrients, calibration of endogenous hormone secretion, and balancing the immune response, we replace traditional methods—such as indiscriminate probiotic supplementation, exogenous hormone administration, or broad-spectrum immune enhancement—with a solution that supports the body's natural restoration of its healthy homeostasis.

6. Precision Wellness: Long-term holistic care spanning three dimensions—physical, mental, and spiritual

Building a tiered, long-term wellness system: The foundational layer focuses on physical well-being, utilizing preliminary screening and intervention systems to eliminate physical ailments and fatigue; the intermediate layer focuses on mental well-being, employing personalized emotional counseling and adjustment of daily rhythms to alleviate chronic anxiety and internal depletion; the core layer focuses on spiritual well-being, establishing a stable source of psychological solace and a healthy social network to achieve holistic mind-body harmony and sustainable health maintenance.

Three core advantages empower the standardization and scaling of industry development.

Compared with traditional health management models, the 146 Longevity Medical Management Model offers distinct advantages in practical implementation, providing a novel paradigm for industrial upgrading. First, it features standardized and replicable processes: the complete service workflow, quality control standards, and intervention guidelines are systematically documented as written specifications, completely eliminating reliance on the individual expertise of seasoned specialists and ensuring consistent service quality across all chain outlets nationwide. Second, it emphasizes distinctive brand differentiation—leveraging proprietary FMT core technologies as its intellectual property and adopting the "standardized framework + personalized customization" as its core tagline, thereby distinguishing itself from the homogeneous and fragmented anti-aging services available on the market. Third, it provides a comprehensive bundled solution that does not sell equipment or individual technologies separately, but instead includes supporting personnel training, intelligent health data management, and a full-process quality control system, offering a one-stop standardized operational solution for the longevity health industry.

Reconceptualizing longevity medicine: replacing blind lifespan extension with healthy longevity

According to available information, human lifespan can be categorized into two major dimensions: chronological age and biological age. Chronological age represents merely an objective record of life duration, whereas biological age is a true indicator of organismal aging—evaluated based on cellular state, metabolic levels, and gene activity—and serves as the core foundation for longevity management. The 146 Longevity Medicine Management Model rejects the unscientific goal of "seeking immortality," instead focusing on shortening the survival period in the presence of disease and extending healthy lifespan; by implementing precise interventions to modulate the biological aging process, it aims to bridge the gap of 8–10 years between total lifespan and healthy lifespan, thereby addressing the societal challenge of "longevity without health."

Empowering industries and improving people's livelihoods! Launching the golden development era for the Longevity Economy

Industry insiders indicate that traditional clinical medicine focuses on treating diseases at their terminal stages and is unable to halt the cumulative effects of aging; in contrast, longevity medicine shifts the medical paradigm forward by achieving a fundamental transformation from "treating existing diseases" to "preventing disease onset, combating aging, preventing illness, and improving quality of life while extending lifespan." At the societal level, it can effectively alleviate the burden of disability and chronic diseases resulting from population aging; at the social level, it can significantly reduce the consumption of public healthcare resources and support the implementation of the active aging strategy; at the industrial level, it drives the standardized and commercialized development of longevity medicine, thereby initiating a golden growth cycle for the industry.

As an upgraded sector within the silver economy, the longevity economy targets all age groups aged 25 and above with a focus on proactive health management, offering multiple industrial dividends. Currently, premature aging and the increasing prevalence of chronic diseases among young and middle-aged populations have become widespread societal needs, enabling this sector to completely transcend the audience limitations of the traditional elderly care industry; amid the absence of industry standards, the "146 Model" has pioneered the establishment of a comprehensive evidence-based service system, thereby creating high industry barriers; simultaneously, it integrates the entire industry chain—including genetic testing, AI-powered anti-aging assessment, microbiome transplantation, multidisciplinary diagnosis and treatment, and long-term wellness care—offering vast value-added potential within this niche sector. Coupled with the entry of public healthcare institutions into this field, the upgrading of national health consumption patterns, and the long-term trend toward population aging, the longevity health industry has emerged as a highly promising growth sector in the broader healthcare landscape over the next decade.

Providing targeted empowerment to four distinct groups to promote scientific concepts of longevity and health

For industrial investors, Longevity Medicine represents a high-barrier blue ocean sector—one that can break free from the homogeneous competition and profit constraints inherent in traditional healthcare and elderly care industries. By leveraging its 146-standardized system, it enables large-scale chain operations and possesses core advantages characterized by strong market demand, high premium pricing, high customer stickiness, and stable returns.

For healthcare professionals, this model can help them escape the vicious cycle of low-end wellness services; by leveraging an evidence-based medicine standardization framework, it enables the development of scientific, full-lifecycle aging intervention solutions, thereby enhancing professional credibility and service premium, and addressing the developmental shortcomings associated with traditional services—such as limited offerings, low repurchase rates, and a lack of systematic support.

For ordinary consumers, this new model challenges the common misconception that aging is irreversible and that medical treatment should only be sought when illness occurs; instead, it demonstrates that aging can be predicted, quantified, and intervened against. It encourages the public to initiate proactive health interventions starting at age 25, replacing folk remedies and unscientific anti-aging practices with a scientific approach to achieve a high-quality long life.

For universities and research institutes, this model establishes an interdisciplinary research framework integrating microecology, immunology, and aging research; it leverages clinical data to support scientific research on aging and chronic diseases, thereby facilitating the generation of original research outcomes. By bridging the "research–validation–industrialization" pipeline, it accelerates the translation of research findings into practical applications. Furthermore, this standardized system can be applied to university training programs, enhance the cultivation of talent in longevity medicine, support both academic research and the development of industry standards, and strengthen the academic influence of research institutions.

epilogue

Against the backdrop of increasingly severe global aging trends, longevity medicine has emerged as a core focus of modern medical development. The 146 Longevity Medicine Management Model released by the Guangdong Sheba Life Science Research Institute effectively fills the gap in the standardization and large-scale implementation of the domestic longevity health management industry, while simultaneously integrating technological innovation, scientific rigor in service delivery, and industrial practicality.

In the future, the team will continue to deepen its efforts in the field of longevity medicine, steadily accumulate multicenter clinical data, refine stratified population intervention criteria, promote the implementation of industry group standards, bridge the gap between basic research and clinical translation, continuously improve the longevity medicine system, and leverage a standardized and scientific health management paradigm to support the implementation of the "Healthy China" strategy, thereby comprehensively enhancing the healthy lifespan and quality of life for all citizens.